Contrast Media Manufacturing Company

For the purpose of medical imaging, a certain substance is introduced into the human body to change the image contrast of local tissues of the body. This introduced substance is Contrast Media, also known as Contrast Agents. As the first Contrast Media manufacturer in China, Beilu Pharma, as one of the most professional contrast media companies, launched the domestic MRI Contrast Media Gadopentetate Dimeglumine Injection in 1992, which broke the foreign products monopoly and filled the domestic gap. As a well-known contrast media company, we could provide various types of MRI contrast and a broad portfolio stems Contrast Media across CT/X-ray and MRI modalities, and own the EU standard manufacturing facilities.

Types of Contrast Media in Beilu Pharma

MRI Contrast Media

Magnetic Resonance Imaging (MRI)Contrast Media is Gadolinium based contrast agent(GBCA). It is an intravenous injection, mainly used to enhance the image quality of internal organs, blood vessels and tissues during MRI examinations. GBCA contains gadolinium, which is connected to each other through carrier molecules to form a chelating agent. According to the different chemical structures, this contrast medium can be divided into two categories: linear and macrocyclic. The linear structure of the imaging agents is easier to release gadolinium ions, and the macrocyclic structure of the contrast material is more stable and less likely to release gadolinium ions.

Gadopentetate Dimeglumine Injection/API

Gadobutrol Injection/API

Gadobenate Dimeglumine Injection

Ferric Ammonium Citrate Effervescent Granules

CT/X-Ray Contrast Media

Iodine-containing Contrast Media is one of the common imaging contrast agents used in radiology diagnosis and interventional therapy. It is also a basic diagnosis drug for cardiovascular imaging under X-ray. Currently, the iodinated Contrast Media used for cardiovascular system CT and digital subtraction angiography are all water-soluble organic iodinated contrast materials.

Iohexol Injection

Iopamidol Injection

Iodixanol Injection

Our dedication to your requirements, providing a full range of Contrast Media products

Finished Types of Contrast Media

S. No	Product name	Characteristic	Specification
1	Gadopentetate Dimeglumine Injection	Injectable solution	469mg/ml: 10ml, 12ml, 15ml, 20ml
2	Gadobutrol Injection	Injectable solution	604.72mg/ml: 7.5ml
3	Ammonium iron citrate	Oral granules	3g：0.6g（Fe 129mg） 6g：1.2g（Fe 258mg）
4	Iopamidol Injection	Injectable solution	300mgI/ml: 50ml, 100ml 370mgI/ml: 50ml, 100ml
5	Iodixanol Injection	Injectable solution	270mgI/ml: 100ml 320mgI/ml: 50ml, 100ml
6	Iohexol Injection	Injectable solution	300mgI/ml: 20ml,50ml,75ml, 100ml 350mgI/ml: 20ml, 50ml, 100ml

API

S. No	Products	CAS NO.	Packings	Classification
1	lohexol	66108-95-0	25Kg/Drum	API
2	lodixanol	92339-11-2	25Kg/Drum	API
3	lopromide	73334-07-3	25Kg/Drum	API
4	lopamidol	60166-93-0	25Kg/Drum	API
5	loversol	87771-40-2	25Kg/Drum	API
6	Gadobutrol	198637-52-4	25Kg/Drum	API
7	Gadoterate Meglumine	92943-93-6	15Kg/Drum	API
8	Gadopentetate Monomeglumine	92923-57-4	25Kg/Drum	API
9	Gadopentetate Dimeglumine	86050-77-3	25Kg/Drum	API
10	Repaglinide	135062-02-1	10Kg/Drum	API
11	Anhydrous Sodium Sulfate	7757-82-6	25Kg/Drum	API

Intermediates

S. No	Products	CAS NO.	Packings	Classification
12	lopamidol Intermediate (order based) 5-Amino-2,4,6- triiodoisophthalic acid	35453-19-1	25Kg/Drum	Intermediates

Excipients

S. No	Products	CAS NO.	Packings	Classification
13	Meglumine	6284-40-8	10Kg/Drum	Excipients
14	Calcobutrol	151878-23-8	2Kg/Drum	Excipients
15	Diethylenetriaminepentaacetic acid ( Pentaacetic Acid)(DTPA)	67-43-6	2.5Kg/Drum	Excipients
16	Sodium Calcium Edetate	62-33-9	150g/Bottle	Excipients
17	Tetraxetan	60239-18-1	2Kg/Drum	Excipients

Comparison of physicochemical characteristics of commonly used Contrast Media

Contrast media (Concentration：mg（I）/ml)	Osmotic pressure (mOsm/kg water）	Viscosity （cP，37℃）
Iopamidol 300	616	4.7
Ioverol 300	651	5.5
Iohexol 300	672	6.3
Iobitridol 300	695	6
Iodixanol 320	290	11.8

The osmotic pressure of normal people is about 290-300mOsm/kg.

Taking the viscosity of water as 1, when the temperature is 37℃, the relative viscosity of whole blood is 4-5, and the relative viscosity of plasma is 1.6-2.4.

Three factors of renal injury induced by Contrast Media: Osmotic pressure, Viscosity and the total iodine. Reduced iodine intake is a feasible strategy to avoid kidney damage.

Document title	Read online	Download
Norms for Safe Use of Iodinated Contrast Media
Reasonable Use of Iodinated Contrast Agents and Management of Adverse Reactions-Beilu Pharma